Cluster	HMM	Locus	Description	COG	Pfam	Smart	Swiss-Prot
3300	3300.hmmls 3300.hmmfs	Ec042-4597 Ec042-3212 YP_001726352.1 YP_001725581.1 YP_001725217.1 YP_001723737.1 c4506 YP_001730401.1 YP_001729201.1 YP_001733038.1 YP_001451392.1 b4284 b1404 b0256 EcN5675 EcN3808 Z2993 Z3936 ECs3505 ECs2647 insI YP_001251461.1	Transposase insI for insertion sequence element IS30B/C/D|Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; COG2826|Integrase core domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022; pfam00665|Escherichia coli K-12 ortholog: b4284; Escherichia coli O157:H7 ortholog: z2993	COG2826(9)	PF00665(7)
4552	4552.hmmls 4552.hmmfs	Ec042-3420 ECP_3219 YP_001723575.1 c3884 YP_001731987.1 YP_001464602.1 EcHS_A3319 b3129 EcN4123 Z4481 ECs4007 sohA	HtrA suppressor protein|predicted regulator; PRK09974
4888	4888.hmmls 4888.hmmfs	Ec042-3894 YP_001723139.1 YP_001732414.1 YP_001465061.1 EcHS_A3789 b3585 Z5004 ECs4461 YP_001745876.1 yiaU YP_001174885.1	transcriptional regulator, LysR family|Transcriptional regulator [Transcription]; COG0583|Bacterial regulatory helix-turn-helix protein, lysR family; pfam00126|LysR substrate binding domain. The structure of this domain is known and is similar to the periplasmic binding proteins; pfam03466	COG0583(5)	PF00126(5)|PF03466(5)
4897	4897.hmmls 4897.hmmfs	Ec042-0386 YP_001726225.1 YP_001730244.1 YP_001461525.1 EcHS_A0413 b0349 Z0447 ECs0404 YP_001742483.1 mhpC KPN_02120	2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase|Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; COG0596|identified by similarity to SP:P77044; match to protein family HMM PF00561	COG0596(6)	PF00561(1)
4898	4898.hmmls 4898.hmmfs	Ec042-0383 YP_001726228.1 YP_001730241.1 YP_001461522.1 EcHS_A0410 b0346 Z0444 ECs0401 YP_001742480.1 mhpR KPN_02123	Mhp operon transcriptional activator|DNA-binding transcriptional activator, 3HPP-binding; PRK09834|helix_turn_helix isocitrate lyase regulation; smart00346|Bacterial transcriptional regulator. This family of bacterial transcriptional regulators includes the glycerol operon regulatory protein and acetate operon repressor both of which are members of the iclR family; pfam01614		PF01614(5), PF01614(1)|PF09339(1)	SM00346(6)
4899	4899.hmmls 4899.hmmfs	Ec042-0378 YP_001726233.1 YP_001730237.1 YP_001461518.1 EcHS_A0406 b0341 Z0437 ECs0394 YP_001742475.1 cynX KPN_02734	cyanate transport protein CynX|predicted cyanate transporter; PRK09705		PF07690(1)
5270	5270.hmmls 5270.hmmfs	Ec042-0377 YP_001726234.1 YP_001730236.1 YP_001461517.1 EcHS_A0405 b0340 Z0436 ECs0393 YP_001742474.1 cynS	cyanate hydratase|Cyanate lyase [Inorganic ion transport and metabolism]; COG1513|Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide; cd00559	COG1513(5)	PF02560(1)
5527	5527.hmmls 5527.hmmfs	Ec042-1531 YP_001725218.1 YP_001730398.1 YP_001462681.1 EcHS_A1487 b1400 paaY KPN_01481	phenylacetic acid degradation protein PaaY|Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; COG0663|Left-Handed Parallel beta-Helix; Alignment contains 4 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X); cd00208	COG0663(4)	PF00132(1)
5859	5859.hmmls 5859.hmmfs	Ec042-3054 YP_001723854.1 YP_001731744.1 YP_001464191.1 EcHS_A3003 Z4178 ECs3713 ygeM	conserved hypothetical protein|identified by similarity to GB:AAA83039.1,
5860	5860.hmmls 5860.hmmfs	Ec042-3053 YP_001723855.1 YP_001731742.1 YP_001464190.1 EcHS_A3002 Z4176 ECs3712 ygeK	transcriptional regulator, LuxR family|Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; COG2197|Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; cl09944|C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; cd06170	COG2197(4)	PF00196(1)
5894	5894.hmmls 5894.hmmfs	Ec042-4379 YP_001726939.1 YP_001732794.1 YP_001465510.1 b4017 Z5608 ECs4935 arpA	ankyrin repeat protein, function unknown|ShET2 enterotoxin, N-terminal region. The members of this family are are sequences that are similar to the N-terminal half of the ShET2 enterotoxin produced by Shigella flexneri and Escherichia coli; pfam07906|ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example); cd00204|GO_component: cytoplasm		PF07906(4)
5896	5896.hmmls 5896.hmmfs	YP_001723560.1 YP_001731999.1 YP_001464617.1 EcHS_A3334 b3142 Z4498 ECs4020 yraH	putative type 1 fimbrial protein|Fimbrial protein; pfam00419|identified by similarity to SP:P22595; match to protein family HMM PF00419		PF00419(5)
5906	5906.hmmls 5906.hmmfs	YP_001725905.1 YP_001729691.1 YP_001461865.1 EcHS_A0750 b0704 Z0853 ECs0730 ybfC	hypothetical protein|ybfC; identified by glimmer; putative,,
5908	5908.hmmls 5908.hmmfs	Ec042-0316 YP_001726281.1 YP_001729230.1 YP_001461450.1 b0286 Z0352 ECs0316 yagT	predicted xanthine dehydrogenase, 2Fe-2S subunit|putative xanthine dehydrogenase iron-sulfur-binding subunit; PRK11433|[2Fe-2S] binding domain; pfam01799		PF01799(4)
5909	5909.hmmls 5909.hmmfs	Ec042-0315 YP_001726282.1 YP_001729229.1 YP_001461449.1 b0285 Z0351 ECs0315 yagS	predicted oxidoreductase with FAD-binding domain|Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; COG1319|FAD binding domain in molybdopterin dehydrogenase; pfam00941	COG1319(4)	PF00941(4)
5910	5910.hmmls 5910.hmmfs	Ec042-0314 YP_001726283.1 YP_001729228.1 YP_001461448.1 b0284 Z0350 ECs0314 yagR	predicted oxidoreductase with molybdenum-binding domain|Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; COG1529|Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; pfam01315	COG1529(4)	PF01315(4)|PF02738(4)
5911	5911.hmmls 5911.hmmfs	Ec042-0313 YP_001726284.1 YP_001729227.1 YP_001461447.1 b0283 Z0349 ECs0313 yagQ	conserved protein|Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; COG1975|XdhC and CoxI family. This domain is often found in association with an NAD-binding region, related to TrkA-N (pfam02254; personal obs:C. Yeats). XdhC is believed to be involved in the attachment of molybdenum to Xanthine Dehydrogenase; pfam02625	COG1975(4)	PF02625(4)