Protein Clusters in Enterobacteria

Cluster	Description	COG	Pfam	Smart	Swiss-Prot
3445	putative RTX family exoprotein\|Residues 1483 to 4111 of 5188 are 35.24 pct identical to residues 373 to 2965 of 3029 from GenPept 118 : gi\|1001461\|dbj\|BAA10087.1\| (D63999) hypothetical protein [Synechocystis sp.]
3591	putative oxalacetate decarboxylase, subunit alpha\|pyruvate carboxylase subunit B; PRK09282\|HMGL-like. This family contains a diverse set of enzymes. These include various aldolases and a region of pyruvate carboxylase; pfam00682\|Biotin-requiring enzyme. This family covers two Prosite entries, the conserved lysine residue binds biotin in one group and lipoic acid in the other. Note that the HMM does not currently recognise the Glycine cleavage system H proteins; pfam00364		PF00682(10)\|PF02436(10)\|PF00364(10)		Q8XGX8(2)
3851	cytochrome d terminal oxidase polypeptide subunit II\|Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; COG1294\|Cytochrome oxidase subunit II. This Family consists of cytochrome bd type terminal oxidases that catalyses Quinol dependent, Na+ independent oxygen uptake. Members of this family are integral membrane proteins and contain a protoheame IX centre B558; pfam02322	COG1294(7)	PF02322(7)
3852	cytochrome oxidase bd-II, subunit I\|Cytochrome bd-type quinol oxidase, subunit 1 [Energy production and conversion]; COG1271	COG1271(3)	PF01654(4)
3869	putative oxaloacetate decarboxylase beta chain\|Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; COG1883	COG1883(12)			Q8Z3E5(1), Q8Z9M6(1)
4053	putative glycoside hydrolase, family 1\|Glycosyl hydrolase family 1; cl01046	COG2723(8)
4139	putative pyruvate decarboxylase\|Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; COG3961\|Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; pfam02776	COG3961(6)	PF02776(6)\|PF00205(6)
4160	putative DSBA oxidoreductase\|DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti; cd03023
4274	formimionoglutamate hydrolase\|formimidoylglutamase; PRK01722,				Q8Z899(1)
4320	possible sulfatase\|Arylsulfotransferase (ASST). This family consists of several bacterial Arylsulfotransferase proteins. Arylsulfotransferase (ASST) transfers a sulfate group from phenolic sulfate esters to a phenolic acceptor substrate; pfam05935		PF05935(6)
4322	hydroxylase for synthesis of 2-methylthio-cis-ribozeatin in tRNA	COG4445(5)
4345	putative sulfatase\|Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; COG3119\|Sulfatase; pfam00884\|Residues 4 to 385 of 493 are 24.34 pct identical to residues 9 to 407 of 512 from GenPept 118 : gi\|3046314\|gb\|AAC13371.1\| (U39940) choline sulfatase [Sinorhizobium meliloti]	COG3119(7)	PF00884(7)
4417	putative tryptophanyl-tRNA synthetase\|Tryptophanyl-tRNA synthetase (TrpRS) catalytic core domain. TrpRS is a homodimer, which attaches Tyr to the appropriate tRNA. TrpRS is a class I tRNA synthetases, so it aminoacylates the 2'-OH of the nucleotide at the 3' end of the tRNA; cd00806
4466	putative permease of the major facilitator superfamily\|alpha-ketoglutarate transporter; PRK10406				P0A2G4(1)
4502	conserved hypothetical protein\|Protein of unknown function (DUF523). Family of uncharacterised bacterial proteins; cl00733		PF08349(1)
4523	putative PagC-like membrane protein\|Residues 7 to 177 of 177 are 45.71 pct identical to residues 23 to 188 of 188 from GenPept 118 : gi\|154233\|gb\|AAA27179.1\| (M55546) virulence protein [Salmonella typhimurium]
4527	unknown protein encoded by prophage CP-933X\|Manganese (Mn) catalase domain is a member of a broad superfamily of ferritin-like diiron enzymes. While many diiron enzymes catalyze dioxygen-dependent reactions, manganese catalase performs peroxide-dependent oxidation-reduction; cd01051\|Residues 1 to 289 of 296 are 84.42 pct identical to residues 1 to 289 of 292 from GenPept 118 : gi\|7162108\|emb\|CAB76676.1\| (Y19180) putative catalase [Salmonella typhimurium]
4531	unknown protein encoded by prophage CP-933K\|Uncharacterized protein conserved in bacteria [Function unknown]; COG3528\|Residues 26 to 304 of 319 are 19.32 pct identical to residues 35 to 320 of 336 from GenPept 118 : gi\|4155189\|gb\|AAD06215.1\| (AE001495) putative Outer membrane protein [Helicobacter pylori J99]	COG3528(7)
4548	UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase\|Glycosyl transferases group 1. Mutations in this domain of phosphatidylinositol N-acetylglucosaminyltransferase subunit A lead to disease (Paroxysmal Nocturnal haemoglobinuria); pfam00534\|GO_function: cell surface antigen activity, host-interacting		PF00534(6)
4549	lipopolysaccharide core biosynthesis protein\|lipopolysaccharide core biosynthesis; GO_component: organelle inner membrane; GO_function: cell surface antigen activity, host-interacting; GO_process: lipopolysaccharide core region biosynthetic process,
4597	putative cytoplasmic protein\|PRD domain. The PRD domain (for PTS Regulation Domain), is the phosphorylatable regulatory domain found in bacterial transcriptional antiterminator such as BglG, SacY and LicT, as well as in activators such as MtlR and LevR; pfam00874		PF00874(6)
4598	putative cytoplasmic protein,,
4603	hypothetical protein\|Bacterial protein of unknown function (DUF903). This family consists of several small bacterial proteins several of which are classified as putative lipoproteins. The function of this family is unknown; pfam06004		PF06004(5)
4611	Suppression of copper sensitivity: lipoprotein modification in lgt mutants of E. coli\|TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; cd03011
4616	hypothetical protein\|Uncharacterized protein conserved in bacteria [Function unknown]; COG3755	COG3755(6)
4619	Methyl viologen resistance; energy-dependent efflux\|multidrug efflux system protein; PRK10504
4620	putative transcriptional regulator, TetR family\|Transcriptional regulator [Transcription]; COG1309\|Bacterial regulatory proteins, tetR family; pfam00440	COG1309(2)	PF00440(6)
4626	putative regulator\|Transcriptional regulator [Transcription]; COG0583\|Bacterial regulatory helix-turn-helix protein, lysR family; pfam00126\|LysR substrate binding domain. The structure of this domain is known and is similar to the periplasmic binding proteins; pfam03466\|Residues 18 to 298 of 318 are 32.28 pct identical to residues 8 to 291 of 342 from GenPept 118 : gi\|1173885\|gb\|AAA86620.1\| (U40823) galactose binding protein regulator [Azospirillum brasilense]	COG0583(5)	PF00126(5)\|PF03466(5)
4627	putative glutamine amidotransferase class-I\|GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; COG0518\|This group contains a subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain. GATase activity catalyses the transfer of ammonia from the amide side chain of glutamine to an acceptor substrate; cd01741	COG0518(5)
4778	Pathogenicity island encoded protein: SPI3\|PipA protein. This family consists of several Salmonella PipA (pathogenicity island-encoded protein A) and related phage sequences. PipA is thought to contribute to enteric but not to systemic salmonellosis; pfam07108\|IPR006025: Neutral zinc metallopeptidases, zinc-binding site		PF07108(6)
4790	anaerobic sulfide reductase\|Oxidoreductase FAD-binding domain; pfam00970\|Oxidoreductase NAD-binding domain. Xanthine dehydrogenases, that also bind FAD/NAD, have essentially no similarity; pfam00175		PF00970(4)\|PF00175(4)
4791	anaerobic sulfide reductase\|Acetyl-CoA synthase (ACS), also known as acetyl-CoA decarbonylase, is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA; cd01916\|IPR001450: 4Fe-4S ferredoxin, iron-sulfur binding domain
4796	Periplasmic dipeptidase for D-ala-D-ala digestion in peptidoglycan\|D-alanyl-D-alanine dipeptidase [Cell envelope biogenesis, outer membrane]; COG2173	COG2173(4)
4804	hypothetical protein\|Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; COG3555	COG3555(5)
4816	putative glutamic dehyrogenase-like protein\|Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; COG0334\|Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; pfam02812\|Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; pfam00208	COG0334(5)	PF02812(5)\|PF00208(5)
4826	putative deoR-family transcriptional regulator\|HTH domain. This family includes helix-turn-helix domains in a wide variety of proteins; pfam08279	COG2378(5)	PF08279(5)
4827	putative amino acid/amine transport protein\|Amino acid transporters [Amino acid transport and metabolism]; COG0833	COG0833(1), COG0531(4)\|COG0833(4)
4833	putative transcriptional regulator\|Helix-turn-helix (HTH) transcription regulator MlrA (merR-like regulator A), N-terminal domain; cd01104,
4857	putative transcription activator\|Mig-14. This family contains a number of bacterial mig-14 proteins (approximately 270 residues long). In Salmonella, mig-14 contributes to resistance to antimicrobial peptides, although the mechanism is not fully understood; pfam07395\|Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; COG5653	COG5653(4)	PF07395(4)
4865	type III secretion apparatus protein\|Salmonella surface presentation of antigen gene type M protein; pfam02090\|Residues 2 to 102 of 111 are 31.68 pct identical to residues 45 to 145 of 147 from GenPept 118 : gi\|1155297\|gb\|AAC44998.1\| (U43304) SpaM [Salmonella enterica]		PF02090(6)
4873	Phosphotransferase system, galactitol-specific IIB component [Carbohydrate transport and metabolism]; COG3414\|Residues 4 to 101 of 106 are 28.57 pct identical to residues 2 to 97 of 101 from GenPept 118 : gi\|1790638\|gb\|AAC77151.1\| (AE000491) orf, hypothetical protein [Escherichia coli]	COG3414(6)
4935	putative methyl-accepting chemotaxis protein\|HAMP domain; pfam00672\|IPR003660: Histidine kinase, HAMP region; IPR004089: Bacterial chemotaxis sensory transducer; IPR004090: Methyl-accepting chemotaxis protein		PF00672(4)
4936	putative permease\|Sugar phosphate permease [Carbohydrate transport and metabolism]; COG2271\|Major Facilitator Superfamily; pfam07690\|IPR007114: Major facilitator superfamily	COG2814(1), COG2271(2)	PF07690(3)
4943	putative S-transferase\|Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; COG0625\|GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III; cd03046	COG0625(6)
4945	putative cytoplasmic protein
4946	putative inner membrane protein,
4947	putative inner membrane protein,,,
4948	putative dihydroorotase\|dihydroorotase; PRK09237\|Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site; cd01307
4949	putative selenocysteine synthase [L-seryl-tRNA(Ser) selenium transferase\|Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; COG1921	COG1921(6)
4950	putative periplasmic protein\|Protein of unknown function (DUF1341). This family consists of several hypothetical bacterial proteins of around 220 residues in length. The function of this family is unknown; pfam07071		PF07071(6)
4951	putative phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type)\|Transcriptional antiterminator [Transcription]; COG3711\|HTH domain. This family includes helix-turn-helix domains in a wide variety of proteins; pfam08279\|Mga helix-turn-helix domain. M regulator protein trans-acting positive regulator (Mga) is a DNA-binding protein that activates the expression of several important virulence genes in group A streptococcus in response to changing environmental conditions; pfam05043	COG3711(6)	PF08279(6)\|PF05043(6)\|PF00874(6)
4953	hypothetical protein\|protein family related to YbaK Protein From H. Influenzae (HI1434); prokaryotic domain; function unknown; alignment contains insertion domains of prokaryotic prolyl-tRNA synthetases; cd00002
4955	putative cytoplasmic protein\|Predicted beta-xylosidase [General function prediction only]; COG3940	COG3940(4)
4956	probable secreted protein,,
4959	putative inner membrane protein,,		PF05437(2)
4960	putative exported protein\|AzlC protein; cl00570
4961	putative helix-turn-helix regulatory protein\|Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; cd00093\|Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; COG1917	COG1917(5)
4964	putative inner membrane protein\|Extensin-like protein C-terminus. This family represents the C-terminus (approx. 120 residues) of a number of bacterial extensin-like proteins; pfam06904	COG3921(4)	PF06904(5)
4965	putative lipoprotein\|ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; COG1464	COG1464(6)
4966	putative regulatory protein\|Transcriptional regulator [Transcription]; COG1309	COG1309(5)	PF00440(4)
4967	putative regulatory protein\|DNA-binding transcriptional activator MarA; PRK11511\|Bacterial regulatory helix-turn-helix proteins, AraC family; pfam00165		PF00165(5)
4973	Suppression of copper sensitivity: putative copper binding protein
4974	Suppression of copper sensitivity protein\|DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti; cd03023
4979	Gifsy-1 prophage DinI\|DinI-like family. This family of short proteins includes DNA-damage-inducible protein I (DinI) and related proteins; pfam06183		PF06183(4)
4982	putative ABC-type transport system ATPase component/cell division protein\|MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein; cd03258\|IPR001687: ATP/GTP-binding site motif A (P-loop); IPR003439: ABC transporter		PF09383(4)
4985	hypothetical protein\|Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; COG3615	COG3615(5)
4986	putative cytoplasmic protein\|Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; COG4225	COG4225(4)
4987	Propanediol utilization\|Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; COG4542	COG4542(7)	PF07000(1)
4988	putative hydroxylase\|salicylate hydroxylase; PRK08163\|Residues 6 to 391 of 397 are 32.41 pct identical to residues 2 to 390 of 406 from GenPept 118 : gi\|2290996\|gb\|AAC46266.1\| (AF006000) unknown [Bordetella pertussis]
4991	putative chemotaxis signal transduction protein\|CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA; cd00732\|Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; contains; cd00156\|IPR001789: Response regulator receiver; IPR002545: CheW-like protein
4992	hypothetical protein\|Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; COG1574\|YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; cd01300	COG1574(6)
4993	putative regulatory protein\|Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; COG1167\|helix_turn_helix gluconate operon transcriptional repressor; smart00345\|Aminotransferase class I and II; pfam00155	COG1167(3)\|COG0436(3), COG1167(1)	PF00155(1)	SM00345(4)
5206	hypothetical protein,,
5207	putative modifier of citrate lyase protein\|Triphosphoribosyl-dephospho-CoA synthetase [Coenzyme metabolism]; COG1767\|ATP:dephospho-CoA triphosphoribosyl transferase. The citG gene is found in a gene cluster with citrate lyase subunits. The function of the CitG protein was elucidated as ATP:dephospho-CoA triphosphoribosyl transferase; pfam01874	COG1767(5)	PF01874(5)
5208	hypothetical protein\|Protein of unknown function (DUF1471). This family consists of several hypothetical Enterobacterial proteins of around 90 residues in length. Some members of this family are annotated as ydgH precursors and contain two copies of this region, one at the...; pfam07338		PF07338(5)
5209	periplasmic protein\|P pilus assembly/Cpx signaling pathway, periplasmic inhibitor/zinc-resistance associated protein [Intracellular trafficking and secretion / Cell motility and secretio / Signal transduction mechanisms / Inorganic ion transport and metabolism]; COG3678	COG3678(4)
5210	hypothetical protein\|Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; COG3382	COG3382(5)
5211	putative regulator, helix-turn-helix motif\|Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; cd00093\|Cupin domain. This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel); pfam07883		PF07883(5)
5212	putative cytoplasmic protein\|SMP-30/Gluconolaconase/LRE-like region. This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species; pfam08450		PF08450(5)
5213	putative potassium channel protein\|Ion transport protein. This family contains Sodium, Potassium, Calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g; pfam00520		PF00520(5)\|PF07885(5)
5214	putative cytoplasmic protein\|Uncharacterized protein conserved in bacteria [Function unknown]; COG4460	COG4460(5)
5215	Gifsy-1 prophage cI protein\|Bacteriophage CII protein. This family consists of several phage CII regulatory proteins. CII plays a key role in the lysis-lysogeny decision in bacteriophage lambda and related phages; pfam05269		PF05269(4)
5239	putative dimethyl sulfoxide reductase subunit C\|DMSO reductase anchor subunit [General function prediction only]; COG3302\|Residues 2 to 272 of 273 are 25.26 pct identical to residues 6 to 276 of 286 from GenPept 118 : gi\|5002126\|gb\|AAD37317.1\|AF135170_8 (AF135170) dimethyl sulfoxide reductase subunit C [Yersinia pestis]	COG3302(6)
5240	MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; COG1149\|No significant matches	COG1149(2)
5246	Uncharacterized protein conserved in bacteria [Function unknown]; COG3037\|Residues 1 to 440 of 447 are 38.18 pct identical to residues 20 to 450 of 484 from GenPept 118 : gi\|2367358\|gb\|AAC77150.1\| (AE000491) orf, hypothetical protein [Escherichia coli]	COG3037(6)
5310	putative inner membrane protein,,
5311	putative cytoplasmic protein,
5312	putative cytoplasmic protein,
5320	putative bacterial regulatory protein, luxR family\|Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; COG2197\|helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon; smart00421	COG2197(4)		SM00421(4)
5328	putative aminotransferase in cobalamin synthesis\|L-threonine-O-3-phosphate decarboxylase; PRK06358				Q8Z8H8(1)
5329	fimbrial morphology\|P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; COG3539	COG3539(5)
5332	putative aspartate racemase\|Aspartate racemase [Cell envelope biogenesis, outer membrane]; COG1794	COG1794(3)
5336	ABC-type proline/glycine betaine transport systems, ATPase component\|OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment; cd03295\|This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA; cd04582\|IPR000644: CBS domain; IPR001687: ATP/GTP-binding site motif A (P-loop); IPR003439: ABC transporter	COG1125(4)
5337	putative binding-protein-dependent transport system, inner membrane component\|ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; COG1174	COG1174(4)
5338	putative periplasmic component, ABC transport system\|Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; COG1732	COG1732(4)	PF04069(4)
5339	ABC-type transport systems, permease components\|IPR000515: Binding-protein-dependent transport systems inner membrane component	COG1174(4)
5343	hypothetical protein\|cobyric acid synthase; PRK00784\|dithiobiotin synthetase; PRK00090\|Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms; cd03109\|Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ). CobQ plays a role in cobalamin biosythesis; cd01750\|synthesis of vitamin B12 adenosyl cobalamide precursor				Q8Z5N6(1)
5344	hypothetical protein\|ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; COG1122\|Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed; cd03225\|synthesis of vitamin B12 adenosyl cobalamide precursor	COG1122(5)			Q8Z5N5(1)
5345	hypothetical protein\|Cobalt transport protein. This family consists of various cobalt transport proteins Most of which are found in Cobalamin (Vitamin B12) biosynthesis operons; pfam02361\|synthesis of vitamin B12 adenosyl cobalamide precursor		PF02361(6)
5346	hypothetical protein\|cobalt-precorrin-2 C(20)-methyltransferase; PRK05576\|synthesis of vitamin B12 adenosyl cobalamide precursor
5347	hypothetical protein\|Precorrin-3B methylase [Coenzyme metabolism]; COG1010\|synthesis of vitamin B12 adenosyl cobalamide precursor	COG1010(6)
5348	hypothetical protein\|cobalamin biosynthesis protein CbiG; PRK05788\|synthesis of vitamin B12 adenosyl cobalamide precursor
5349	hypothetical protein\|Precorrin-4 methylase [Coenzyme metabolism]; COG2875\|synthesis of vitamin B12 adenosyl cobalamide precursor	COG2875(6)			P0A2H0(1)
5350	hypothetical protein\|cobalt-precorrin-6Y C(15)-methyltransferase; PRK08287\|synthesis of vitamin B12 adenosyl cobalamide precursor,				Q8Z5M9(1)
5351	hypothetical protein\|cobalt-precorrin-6Y C(5)-methyltransferase; PRK05787\|synthesis of vitamin B12 adenosyl cobalamide precursor				P0A2H2(1)
5352	hypothetical protein\|Cobalamin biosynthesis protein CbiD [Coenzyme metabolism]; COG1903\|synthesis of vitamin B12 adenosyl cobalamide precursor	COG1903(6)			Q8Z5M8(1)
5353	hypothetical protein\|Cobalamin biosynthesis protein CobD/CbiB [Coenzyme metabolism]; COG1270\|synthesis of vitamin B12 adenosyl cobalamide precursor	COG1270(5)			Q8Z5M7(1)
5355	putative transketolase\|Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; COG3958\|Transketolase, pyrimidine binding domain. This family includes transketolase enzymes, pyruvate dehydrogenases, and branched chain alpha-keto acid decarboxylases; pfam02779	COG3958(4)	PF02779(4)\|PF02780(4)
5356	putative periplasmic protein,
5357	hypothetical protein
5358	putative periplasmic protein\|Cellulase (glycosyl hydrolase family 5); pfam00150		PF00150(4)
5453	putative SAM-dependent methyltransferase\|arsenite S-adenosylmethyltransferase; PRK11873\|Methyltransferase domain. Members of this family are SAM dependent methyltransferases; pfam08241\|tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; COG2519\|IPR000051: SAM (and some other nucleotide) binding motif; IPR001601: Generic methyltransferase	COG2519(4)	PF08241(6)
5455	TypeIII-secreted protein effector: invasion-associated protein\|Salmonella type III secretion SopE effector N-terminus. Salmonella typhimurium employs a type III secretion system to inject bacterial toxins into the host cell cytosol; pfam05364		PF05364(4)\|PF07487(4)		Q9RPM6(1)
5456	Tetrathionate reductase complex: response regulator\|Response regulator [Signal transduction mechanisms]; COG4566\|Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; contains; cd00156\|helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon; smart00421\|IPR000792: Bacterial regulatory protein, LuxR family; IPR001789: Response regulator receiver	COG4566(4)		SM00421(5)
5457	Tetrathionate reductase complex, subunit C\|Polysulphide reductase, NrfD. NrfD is an integral transmembrane protein with loops in both the periplasm and the cytoplasm. NrfD is thought to participate in the transfer of electrons, from the quinone pool into the terminal components of the Nrf pathway; pfam03916		PF03916(4)
5458	Tetrathionate reductase complex, subunit A\|The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate; cd02758
5459	Pathogenicity island encoded protein: SPI3\|Dipeptidase [Amino acid transport and metabolism]; COG4690	COG4690(3)
5461	putative inner membrane protein\|Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; COG1495	COG1495(4)
5463	putative transcriptional regulatory protein\|Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment; cd00383	COG3710(4)
5464	hypothetical protein\|predicted DNA-binding transcriptional regulator; PRK11832
5465	putative phosphatase/sulfatase\|Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; COG3119\|Sulfatase; pfam00884,,	COG3119(3)	PF00884(4)
5466	putative beta-glucoside kinase\|Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; COG1940\|N-acetylmannosamine kinase; PRK05082	COG1940(5)	PF00480(4)
5467	putative transporter\|putative sialic acid transporter; PRK03893\|Major Facilitator Superfamily; pfam07690		PF07690(5)
5468	putative bacterial regulatory protein, LuxR\|helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon; smart00421			SM00421(5)
5471	putative transcriptional regulator\|Transcriptional regulator [Transcription]; COG1414\|IclR helix-turn-helix domain; pfam09339\|IPR005471: Bacterial regulatory proteins, IclR family	COG1414(4)	PF09339(4)
5472	hypothetical protein\|Uncharacterized conserved protein [Function unknown]; COG3791	COG3791(5)
5474	putative periplasmic protein,
5475	putative permease\|Major Facilitator Superfamily; pfam07690\|multidrug efflux system protein; PRK10504	COG2814(3)	PF07690(4)
5476	putative transcriptional regulators, LysR family\|predicted DNA-binding transcriptional regulator, efflux system; PRK10632\|Bacterial regulatory helix-turn-helix protein, lysR family; pfam00126\|LysR substrate binding domain. The structure of this domain is known and is similar to the periplasmic binding proteins; pfam03466	COG0583(3)	PF00126(4)\|PF03466(4)
5477	putative chaperone\|P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; COG3121\|Gram-negative pili assembly chaperone, N-terminal domain. C2 domain-like beta-sandwich fold; pfam00345	COG3121(5)	PF00345(5)\|PF02753(5)
5478	bacterial regulatory helix-turn-helix proteins, araC family\|AraC-type DNA-binding domain-containing proteins [Transcription]; COG2207\|IPR000005: Helix-turn-helix, AraC type	COG2207(4)	PF00165(4)		Q8Z4A6(1)
5479	putatiave helix-turn-helix regulatory protein\|Predicted transcriptional regulator [Transcription]; COG3423	COG3423(4)
5482	Hypothetical protein\|Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; COG2189\|Residues 2 to 668 of 670 are 43.91 pct identical to residues 3 to 634 of 636 from GenPept.129 : >gb\|AAK02782.1\| (AE006106) unknown [Pasteurella multocida]	COG2189(5)
5483	putative cytoplasmic protein,
5492	putative FMN-dependent dehydrogenase\|L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2; cd04737	COG1304(1)	PF01070(4)
5500	Protein of unknown function (DUF1401). This family consists of several hypothetical bacterial proteins of around 135 residues in length; pfam07180		PF07180(6)
5506	putative dimethyl sulfoxide reductase subunit B\|Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; COG0437\|Residues 4 to 134 of 145 are 61.83 pct identical to residues 57 to 186 of 205 from GenPept 118 : gi\|1787122\|gb\|AAC73981.1\| (AE000191) anaerobic dimethyl sulfoxide reductase subunit B [Escherichia coli]	COG0437(6)
5572	putative cytoplasmic protein\|Protein of unknown function (DUF1341). This family consists of several hypothetical bacterial proteins of around 220 residues in length. The function of this family is unknown; pfam07071		PF07071(4)
5574	putative diadenosine tetraphosphate (Ap4A) hydrolase\|HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; cd01277\|IPR001310: Histidine triad (HIT) protein
5575	molybdate transport protein (ABC superfamily, peri_bind)\|hypothetical protein; PRK03537,
5577	tricarboxylic transport,,,
5578	tricarboxylic transport\|Uncharacterized protein conserved in bacteria [Function unknown]; COG3181	COG3181(4)	PF0065(1)
5579	tricarboxylic transport: regulatory protein\|Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; COG0745\|Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; contains; cd00156\|IPR001789: Response regulator receiver; IPR001867: Transcriptional regulatory protein, C terminal; IPR005829: Sugar transporter superfamily	COG0745(4)
5580	tricarboxylic transport: regulatory protein\|Two-component sensor kinase N-terminal. This domain is found in bacterial two-component sensor kinases towards the N-terminus; pfam08521\|His Kinase A (phosphoacceptor) domain. Dimerisation and phosphoacceptor domain of histidine kinases; pfam00512\|Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; cd00075		PF08521(4)\|PF00512(4)
5590	putative outer membrane protein\|Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface; cd00342
5591	putative binding-protein-dependent transport systems inner membrane component\|ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; COG2011	COG2011(4)
5595	putative nitric oxide reductase,
5597	putative carboxylesterase\|Carboxylesterase type B [Lipid metabolism]; COG2272\|Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine; cd00312	COG2272(3)
5603	putative cytoplasmic protein
5604	hypothetical protein\|ABC-type cobalt transport system, periplasmic component [Inorganic ion transport and metabolism]; COG1930\|synthesis of vitamin B12 adenosyl cobalamide precursor	COG1930(5)			Q8Z5N3(1)
5606	putative transcriptional regulator\|Helix-turn-helix XRE-family like proteins; smart00530			SM00530(4)
5607	putative phosphoserine phosphatase\|Phosphoserine phosphatase [Amino acid transport and metabolism]; COG0560	COG0560(4)
5610	heat shock protein\|Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; COG0071\|alpha-crystallin-type heat shock proteins (Hsps), family of small stress induced proteins ranging from 12 -43 kDa, whose common feature is the alpha-crystallin domain. They are generally active as large oligomers consisting of multiple subunits; cd00298	COG0071(4)
5721	putative dienelactone hydrolase\|Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; COG0412\|IPR008262: Lipase, active site	COG0412(4)
5722	putative inner membrane or exported\|Uncharacterized conserved protein [Function unknown]; COG3439\|IPR005180: Protein of unknown function DUF302	COG3439(4)
5723	putative cytoplasmic protein,
5724	putative AraC-type DNA-binding domain-containing protein\|DNA-binding transcriptional dual regulator; PRK09978\|helix_turn_helix, arabinose operon control protein; smart00342\|Bacterial regulatory helix-turn-helix proteins, AraC family; pfam00165\|IPR000005: Helix-turn-helix, AraC type		PF00165(4)	SM00342(4)
5725	putative bacterial regulatory proteins, luxR family\|helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon; smart00421			SM00421(4)
5726	putative periplasmic or exported protein\|Domain of unknown function (DUF1996). This family of proteins are functionally uncharacterised; pfam09362		PF09362(4)
5727	putative ABC-type bacteriocin/lantibiotic exporter, contain an N-terminal double-glycine peptidase domain\|ABC-type bacteriocin exporters; cd03245\|The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles; cd03301\|IPR000508: Signal peptidase; IPR001687: ATP/GTP-binding site motif A (P-loop); IPR003439: ABC transporter	COG2274(4)
5728	membrane permease, predicted cation efflux pump\|Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; COG0845\|IPR003997: Gram-negative bacterial RTX secretion protein D	COG0845(4)
5729	putative ABC exporter outer membrane component homolog\|Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; COG1538\|Outer membrane efflux protein. The OEP family (Outer membrane efflux protein) form trimeric channels that allow export of a variety of substrates in Gram negative bacteria. Each member of this family is composed of two repeats; pfam02321	COG1538(4)	PF02321(4)
5730	putative methyl-accepting chemotaxis protein
5731	putative inner membrane or exported\|hypothetical protein; PRK09039
5732	putative outer membrane protein\|Oligogalacturonate-specific porin protein (KdgM). This family consists of several bacterial proteins which are homologous to the oligogalacturonate-specific porin protein KdgM from Erwinia chrysanthemi; pfam06178		PF06178(4)		P0A1U9(1)
5733	putative Zn-dependent hydrolase, including glyoxylases,	COG0491(4)
5734	putative transcriptional regulator, LysR family\|Transcriptional regulator [Transcription]; COG0583\|Bacterial regulatory helix-turn-helix protein, lysR family; pfam00126\|LysR substrate binding domain. The structure of this domain is known and is similar to the periplasmic binding proteins; pfam03466\|IPR000847: Bacterial regulatory protein LysR, HTH motif	COG0583(4)	PF00126(4)\|PF03466(4)
5735	putative phage endolysin\|Endolysins and autolysins are found in viruses and bacteria, respectively; cd00737
5736	putative regulatory protein, gntR family\|Transcriptional regulators [Transcription]; COG2188\|Bacterial regulatory proteins, gntR family. This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerisation domain; pfam00392\|UTRA domain. The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345; pfam07702	COG2188(4)	PF00392(4)\|PF07702(4)
5737	putative phosphosugar isomerase\|Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; COG2222\|SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; pfam01380\|IPR001347: Sugar isomerase (SIS)	COG2222(1)	PF01380(4)
5738	putative methyl-accepting chemotaxis protein\|Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis; smart00283\|hypothetical protein; PRK09894			SM00283(4)
5739	putative amidohydrolase\|Predicted amidohydrolase [General function prediction only]; COG0388\|IPR000276: Rhodopsin-like GPCR superfamily; IPR003010: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase	COG0388(4)
5740	putative integral membrane protein\|Predicted permeases [General function prediction only]; COG2962\|IPR000620: Protein of unknown function DUF6; IPR004626: RarD protein	COG2962(4)
5741	secreted protein in the Sop family; transferred to eukaryotic cells
5742	putative cytoplasmic protein
5743	surface presentation of antigens; secretory proteins\|Surface presentation of antigens protein. Surface presentation of antigens protein (SPAN), also know as invasion protein invJ, is a Salmonella secretory pathway protein involved in presentation of determinants required for mammalian host cell invasion; pfam02510		PF02510(4)
5744	cell invasion protein\|Salmonella invasion protein A. Salmonella invasion protein A is an actin-binding protein that contributes to host cytoskeletal rearrangements by stimulating actin polymerisation and counteracting F-actin destabilising proteins; pfam09052		PF09052(3)		P74849(1)
5745	putative acyl carrier protein\|IPR003231: Acyl carrier protein (ACP); IPR006163: Phosphopantetheine-binding domain				Q8Z495(1)
5746	chaparone, related to virulence,,,				Q8Z497(1)
5747	protein tyrosine phosphate\|SicP binding. Members of this family bind the chaperone SicP, which is required both to maintain the stability of SptP, as well as to ensure the eventual secretion of the protein; pfam09119\|GTPase-activating protein (GAP) domain found in bacterial cytotoxins, ExoS, SptP, and YopE. Part of protein secretion system; stimulates Rac1- dependent cytoskeletal changes that promote bacterial internalization; cd00219\|Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways; cd00047		PF09119(4)		P74851(1)
5748	regulatory helix-turn-helix proteins, araC family\|helix_turn_helix, arabinose operon control protein; smart00342\|IPR000005: Helix-turn-helix, AraC type		PF00165(4)	SM00342(4)
5749	putative inner membrane protein\|Bacterial type III secretion apparatus protein (OrgA_MxiK); pfam09482		PF09482(4)
5750	putative flagellar biosynthesis/type III secretory pathway protein\|type III secretion system protein; PRK06937
5751	putative cytoplasmic protein
5752	transcriptional regulator\|Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; COG2197\|IPR000792: Bacterial regulatory protein, LuxR family	COG2197(4)\|COG2771(4)
5753	putative cytoplasmic protein,,
5754	anaerobic sulfide reductase\|IPR001450: 4Fe-4S ferredoxin, iron-sulfur binding domain; IPR006066: Nitrite and sulfite reductase iron-sulfur/siroheme-binding site	COG2221(3)	PF03460(3)\|PF01077(3)		P0A1Y3(1)
5755	putative cytoplasmic protein\|IPR000345: Cytochrome c heme-binding site
5756	putative cell wall-associated hydrolase\|NlpC/P60 family. The function of this domain is unknown. It is found in several lipoproteins; pfam00877		PF00877(4)
5757	hypothetical protein
5758	putative outer membrane lipoprotein\|Bacterial protein of unknown function (DUF903). This family consists of several small bacterial proteins several of which are classified as putative lipoproteins. The function of this family is unknown; pfam06004		PF06004(4)
5759	putative serine/threonine protein kinase
5760	putative outer membrane or exported,
5761	putative membrane protein UgtL\|similar to chitinase from Schizosaccharomyces
5762	putative outer membrane or secreted lipoprotein\|Protein of unknown function (DUF1264). This family contains a number of bacterial and eukaryotic proteins of unknown function that are approximately 200 residues long. Some family members are annotated as putative lipoproteins; pfam06884		PF06884(4)
5763	putative alpha amylase\|1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; COG0296\|Maltooligosyl trehalose synthase (MTSase) N-terminus domain. MTSase and maltooligosyl trehalose trehalohydrolase (MTHase) work together to produce trehalose; cd02853\|Alpha amylase, catalytic domain. Alpha amylase is classified as family 13 of the glycosyl hydrolases. The structure is an 8 stranded alpha/beta barrel containing the active site, interrupted by a 70 a.a; pfam00128	COG0296(4)	PF00128(4)
5764	putative glycosyl hydrolase\|Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; COG3280\|Alpha-amylase domain; smart00642	COG3280(4)		SM00642(4)
5765	putative Ni/Fe-hydrogenase 1 b-type cytochrome subunit	COG1969(3)
5766	putative hydrogenase maturation protease\|protein involved in processing of HyaA and HyaB proteins; PRK10264\|IPR000671: Hydrogen uptake protein
5767	putative hydrogenase\|HyaE family; HyaE is also called HupG and HoxO; cd02965
5768	putative hydrogenase\|HupH hydrogenase expression protein, C-terminal conserved region. This family represents a C-terminal conserved region found in these bacterial proteins necessary for hydrogenase synthesis. Their precise function is unknown; pfam04809\|Rubredoxin [Energy production and conversion]; COG1773\|Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc; cd00730\|IPR001052: Rubredoxin; IPR004039: Rubredoxin-type Fe(Cys)4 protein	COG1773(4)	PF04809(4)
5769	putative dehydrogenase protein\|Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; COG3259,,	COG3259(2)
5770	Tetrathionate reductase complex: sensory transduction histidine kinase\|ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; COG3221\|His Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylat; cd00082\|Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; cd00075\|IPR003594: ATP-binding region, ATPase-like; IPR003661: Histidine kinase A, N-terminal; IPR004358: Bacterial sensor protein, C-terminal;IPR005467: Histidine kinase	COG3221(1), COG3221(3)\|COG4191(3)
5771	Tetrathionate reductase complex, subunit B\|Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; COG0437\|IPR001450: 4Fe-4S ferredoxin, iron-sulfur binding domain	COG0437(4)
5773	putative transcriptional regulator\|Helix-turn-helix (HTH) multidrug-efflux transporter transcription regulator, BltR (BmrR-like transporter) of Bacillus subtilis, and related proteins; N-terminal domain; cd04782\|IPR000551: Bacterial regulatory protein, MerR family
5774	putative cytoplasmic protein,,
5775	putative inner membrane protein\|Mechanosensitive ion channel. Two members of this protein family in M. jannaschii have been functionally characterised; pfam00924		PF00924(4)
5776	putative outer membrane lipoprotein
5777	putative envelope protein\|Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction; cd00161\|Ricin-type beta-trefoil lectin domain; pfam00652		PF00652(4)
5778	hypothetical protein\|Protein of unknown function (DUF1353). This family consists of several hypothetical bacterial proteins of around 100 residues in length. The function of this family is unknown; pfam07087		PF07087(5)
5779	putative cytoplasmic protein\|Predicted flavin-nucleotide-binding protein [General function prediction only]; COG3467	COG3467(4)
5780	putative hydrogenase protein\|DMSO reductase anchor subunit [General function prediction only]; COG3302	COG3302(4)
5781	putative hydrogenase protein\|Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; COG0437\|IPR001450: 4Fe-4S ferredoxin, iron-sulfur binding domain	COG0437(4)
5782	putative oxidoreductase protein\|Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; COG0243\|The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site; cd02766	COG0243(4)
5783	outer membrane N-acetyl phenylalanine beta-naphthyl ester-cleaving esterase\|Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases; cd01846\|Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; COG5571\|IPR001087: Lipolytic enzyme, G-D-S-L family	COG5571(4)
5784	putative cytoplasmic protein,
5785	putative secreted protein,,
5786	putative membrane protein\|DNA-binding winged-HTH domains [Transcription]; COG3710	COG3710(4)
5787	hypothetical protein,,
5788	fimbrial subunit\|P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; COG3539	COG3539(4)
5789	fimbrial chaparone\|Gram-negative pili assembly chaperone, N-terminal domain. C2 domain-like beta-sandwich fold; pfam00345\|IPR001525: C-5 cytosine-specific DNA methylase; IPR001829: Bacterial pili assembly chaperone	COG3121(3)	PF00345(4)\|PF02753(4)
5790	putative protein\|Predicted lysozyme (DUF847). This family consists of several hypothetical bacterial sequences as well as one viral sequence, P5 from Pseudomonas phage phi8; the function of this family is unknown; pfam05838\|Predicted Peptidoglycan domain. This family contains a potential peptidoglycan binding domain; pfam09374		PF05838(4)\|PF09374(4)
5791	putative bacteriophage protein,,
5792	putative transcriptional regulator, LysR family\|Transcriptional regulator [Transcription]; COG0583\|Bacterial regulatory helix-turn-helix protein, lysR family; pfam00126\|LysR substrate binding domain. The structure of this domain is known and is similar to the periplasmic binding proteins; pfam03466	COG0583(4)	PF00126(4)\|PF03466(4)
5799	putative fimbrial-like protein\|Fimbrial protein; pfam00419	COG3539(4)	PF00419(1)
5802	hypothetical protein\|Uncharacterized protein conserved in bacteria [Function unknown]; COG4332	COG4332(5)
5803	hypothetical protein\|Bacterial protein of unknown function (DUF903). This family consists of several small bacterial proteins several of which are classified as putative lipoproteins. The function of this family is unknown; pfam06004		PF06004(5)
5805	putative transcriptional regulator, LysR family\|Transcriptional regulator [Transcription]; COG0583\|Bacterial regulatory helix-turn-helix protein, lysR family; cl09147\|Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; cl00115	COG0583(5)
5806	hypothetical protein\|Predicted enzyme of the cupin superfamily [General function prediction only]; COG3450	COG3450(5)
5807	putative amino acid/amine transport protein\|Amino acid permease; pfam00324	COG0833(4)	PF00324(1)
5808	hypothetical protein,,
5809	putative bacterial regulatory protein, LuxR\|DNA-binding transcriptional activator; PRK10188\|helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon; smart00421			SM00421(5)
5811	probable secreted protein,,
5812	putative citrate lyase acyl carrier protein (gamma chain)\|Citrate lyase, gamma subunit. In citrate-utilising prokaryotes, citrate lyase EC:4.1.3.6 cleaves intracellular citrate into acetate and oxaloacetate, and is organised as a functional complex consisting of alpha, beta, and gamma subunits; pfam04953	COG3052(4)	PF04953(1)		Q8XFF4(1)
5814	hypothetical protein
5815	putative methyl-accepting chemotaxis protein\|IPR003660: Histidine kinase, HAMP region; IPR004089: Bacterial chemotaxis sensory transducer; IPR004090: Methyl-accepting chemotaxis protein		PF00672(2)
5818	putative lipoprotein\|Protein of unknown function (Chp_urease_rgn). This conserved hypothetical protein of unknown function is found in several Proteobacteria. Its function is unknown and its genome context is not well-conserved; pfam09601\|identified by match to protein family HMM TIGR02117		PF09601(5)
5819	hypothetical protein
5830	Hypothetical protein\|Restriction endonuclease [Defense mechanisms]; COG3587\|DEAD-like helicases superfamily; smart00487\|Residues 1 to 1022 of 1023 are 51.23 pct identical to residues 1 to 1041 of 1043 from GenPept.129 : >gb\|AAK02783.1\| (AE006106) unknown [Pasteurella multocida],	COG3587(3), COG3587(1)\|COG3421(1)	PF04851(2)\|PF08774(2)	SM00487(2)
5978	putative ATP-dependent RNA helicase-like protein
5991	fimbrial protein internal segment\|Fimbrial protein; pfam00419		PF00419(3)
5992	putative regulatory protein\|IPR000792: Bacterial regulatory protein, LuxR family,
6000	putative endochitinase\|Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; COG3979\|Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers; cd00325	COG3979(3)
6002	putative cytoplasmic protein\|Uncharacterized conserved protein [Function unknown]; COG3791	COG3791(2)
6138	putative oxalacetate decarboxylase, subunit gamma\|oxaloacetate decarboxylase subunit gamma; PRK02919,				Q8Z9M5(1)
6139	putative transcriptional regulator\|Transcriptional regulators [Transcription]; COG1609\|helix_turn _helix lactose operon repressor; smart00354\|IPR000843: Bacterial regulatory protein LacI, HTH motif; IPR001761: Periplasmic binding protein/LacI transcriptional regulator	COG1609(4)		SM00354(4)
6140	putative inner membrane protein,
6141	putative outer membrane lipoprotein
6142	putative arginine-binding periplasmic protein\|Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic i; cd00134\|IPR001311: Solute-binding protein/glutamate receptor; IPR001638: Bacterial extracellular solute-binding protein, family 3
6143	hypothetical protein
6144	putative component of anaerobic dehydrogenases	COG3381(4)
6145	Pathogenicity island encoded protein: SPI3\|Pentapeptide repeats (8 copies). These repeats are found in many cyanobacterial proteins. The repeats were first identified in hglK. The function of these repeats is unknown. The structure of this repeat has been predicted to be a beta-helix; pfam00805\|IPR000169: Eukaryotic thiol (cysteine) protease	COG1357(1)	PF00805(4)
6146	lysosomal glycoprotein (lgp)-containing structures; replication in macrophages\|secreted effector protein; PRK09498
6147	putative periplasmic protein\|Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; COG4461	COG4461(4)
6148	PhoP regulated,
6149	putative cytoplasmic protein\|Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; COG4692	COG4692(4)
6150	Secretion system apparatus SsaB,				Q8Z6L0(1)
6151	Secretion system effector SsaE,
6152	Secretion system effector SseA,
6153	Secretion system effector SseB\|EspA-like secreted protein. EspA if the prototypical member of this family. EspA, together with EspB, EspD and Tir are exported by a type III secretion system. These proteins are essential for attaching and effacing lesion formation; pfam03433		PF03433(4)
6154	Secretion system chaparone SscA\|Uncharacterized protein conserved in bacteria [Function unknown]; COG1729\|IPR005415: Gram-negative bacterial type III secretion SycD chaperone	COG1729(4)
6155	Secretion system effector SseC\|Secretion system effector C (SseC) like family. SseC is a secreted protein that forms a complex together with SecB and SecD on the surface of Salmonella. All these proteins are secreted by the type III secretion system; pfam04888\|Uncharacterized conserved protein [Function unknown]; COG5613	COG5613(4)	PF04888(4)
6156	Secretion system effector SseD,
6157	Secretion system effector SseE\|Type III secretion system regulator (LcrR). This family of proteins are encoded within type III secretion operons and have been characterised in Yersinia as a regulator of the Low-Calcium Response (LCR); pfam09621		PF09621(4)
6158	Secretion system chaparone SscB\|Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, pl; cd00189
6159	Secretion system effector SseF,
6160	Secretion system effector SseG,
6161	Secretion system apparatus SsaI\|Bacterial type III secretion system protein (yscI_hrpB_dom). This entry consists of bacterial type III secretion system proteins which share a conserved C-terminal domain; pfam09525		PF09525(4)
6162	putative cytoplasmic protein
6163	Secretion system apparatus SsaK\|type III secretion system protein; PRK06937
6164	Secretion system apparatus SsaO
6165	Secretion system apparatus SsaP,				P0A240(1)
6166	putative cytoplasmic protein,
6167	putative inner membrane protein,,
6169	putative inner membrane protein,,
6170	putative cytoplasmic protein\|predicted protein; PRK11836
6171	putative amino acid transporter\|Amino acid transporters [Amino acid transport and metabolism]; COG0833\|IPR002293: Amino acid/polyamine transporter, family I	COG0833(4)
6172	putative cytoplasmic protein\|Predicted amino acid racemase [Amino acid transport and metabolism]; COG3457\|Alanine racemase. This CD corresponds to alanine racemases, the prototype of the alanine racemase superfamily; cd00430	COG3457(3)
6173	putative diaminopimelate decarboxylase\|Diaminopimelate decarboxylase [Amino acid transport and metabolism]; COG0019\|PLP dependent enzymes class III (PLPDE_III). The prototype of this CD, yeast hypothetical protein YBL036c, is homologous to a P. aeruginosa gene that is co-transcribed with a known proline biosynthetic gene; cd00635\|Pyridoxal-dependent decarboxylase, C-terminal sheet domain. These pyridoxal-dependent decarboxylases act on ornithine, lysine, arginine and related substrates; pfam00278\|IPR000183: Orn/DAP/Arg decarboxylase 2	COG0019(4)	PF00278(4)
6174	putative regulatory protein\|PAS fold. The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya; pfam08448\|phage shock protein operon transcriptional activator; PRK11608\|Sigma-54 interaction domain; pfam00158\|Bacterial regulatory protein, Fis family; pfam02954		PF08448(4)\|PF00158(4)\|PF02954(4)
6175	Homolog of pipB, putative pentapeptide repeats (8 copies)\|Pentapeptide repeats (8 copies). These repeats are found in many cyanobacterial proteins. The repeats were first identified in hglK. The function of these repeats is unknown. The structure of this repeat has been predicted to be a beta-helix; pfam00805		PF00805(4)
6176	putative inner membrane protein\|predicted DNA-binding transcriptional regulator; PRK11832
6177	conserved hypothetical protein\|Protein of unknown function (DUF796). This family consists of several bacterial proteins of unknown function; pfam05638		PF05638(3)
6178	putative pemease\|Sugar phosphate permease [Carbohydrate transport and metabolism]; COG2271\|Major Facilitator Superfamily; pfam07690\|IPR007114: Major facilitator superfamily	COG2271(4)	PF07690(4)
6179	putative C4-dicarboxylate transport system\|TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; COG3090	COG3090(4)
6180	putative bacterial regulatory proteins, lacI family\|helix_turn _helix lactose operon repressor; smart00354\|Transcriptional regulators [Transcription]; COG1609\|IPR000843: Bacterial regulatory protein LacI, HTH motif; IPR001761: Periplasmic binding protein/LacI transcriptional regulator	COG1609(4)		SM00354(4)
6181	putative PQQ enzyme repeat
6183	putative permease\|GntP family permease. This is a family of integral membrane permeases that are involved in gluconate uptake. E. coli contains several members of this family including GntU, a low affinity transporter and GntT, a high affinity transporter; pfam02447		PF02447(4)
6184	invasion protein\|InvH outer membrane lipoprotein. This family represents the Salmonella outer membrane lipoprotein InvH; pfam04741		PF04741(4)
6185	Hydrogen sulfide production: membrane anchoring protein\|Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; COG0243\|The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate; cd02755\|IPR006655: Prokaryotic molybdopterin oxidoreductase	COG0243(3)
6186	putative 50S ribosomal protein,,
6187	putative cytoplasmic protein,
6188	putative cytoplasmic protein,,
6189	putative thiol peroxidase\|Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx); cd03014
6190	hypothetical protein
6191	putative periplasmic protein\|Uncharacterized conserved protein [Function unknown]; COG2353\|IPR007372: YceI	COG2353(4)
6192	cryptic aminoglycoside resistance gene\|Acetyltransferase (GNAT) family. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins; pfam00583		PF00583(4)
6194	putative outer membrane protein\|Ketosteroid isomerase homolog [Function unknown]; COG4319	COG4319(4)
6195	putative cytoplasmic protein\|Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; COG3157\|IPR008514: Protein of unknown function DUF796	COG3157(4)
6196	putative periplasmic protein,,
6197	putative periplasmic protein\|tricarballylate dehydrogenase; PRK08274\|D-amino acid dehydrogenase small subunit; PRK00711
6198	citB-like protein\|Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; COG4656	COG4656(3)
6199	putative hydroxymethyltransferase,,
6210	cyanate transport\|Predicted membrane protein [Function unknown]; COG3326,,,	COG3326(4)
6214	2-aminoethylphosphonate transport\|Predicted phosphatase/phosphohexomutase [General function prediction only]; COG0637	COG0637(5)
6215	2-aminoethylphosphonate transport\|Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; COG0075	COG0075(5)
6216	2-aminoethylphosphonate transporter, periplasmic-binding component\|Bacterial extracellular solute-binding protein. This family also includes the bacterial extracellular solute-binding protein family POTD/POTF; pfam01547\|ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; COG1840	COG1840(5)	PF01547(5)
6217	2-aminoethylphosphonate transporter, membrane component\|ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; COG0555	COG0555(5)
6218	2-aminoethylphosphonate transporter, membrane component\|ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; COG1177	COG1177(4)
6219	putative regulatory protein, gntR family\|Bacterial regulatory proteins, gntR family. This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerisation domain; pfam00392\|Transcriptional regulators [Transcription]; COG1802	COG1802(5)	PF00392(5)
6220	putative regulatory protein, gntR family\|Transcriptional regulators [Transcription]; COG2186\|Bacterial regulatory proteins, gntR family. This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerisation domain; pfam00392	COG2186(3), COG1802(1)	PF00392(4)\|PF07729(4)
6222	hypothetical protein,,
6223	hypothetical protein
6224	regulator for leucine (or lrp) regulon and high-affinity branched-chain amino acid transport system\|Transcriptional regulators [Transcription]; COG1522\|helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli); smart00344	COG1522(5)	PF01037(4)	SM00344(5)
6225	conserved hypothetical protein\|Predicted enzyme related to lactoylglutathione lyase [General function prediction only]; COG3324	COG3324(5)
6226	putative transcription regulator sensor for citrate\|Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; COG4565\|Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; contains; cd00156	COG4565(5)
6229	putative cytoplasmic protein\|Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; COG3697	COG3697(4)
6436	putative fimbrial protein\|IPR000792: Bacterial regulatory protein, LuxR family,
6438	putative chitinase\|Chitinase [Carbohydrate transport and metabolism]; COG3325\|Glycosyl hydrolases family 18; pfam00704\|Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; COG3979\|Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; cd00036	COG3325(2)\|COG3979(2)	PF00704(2)
6531	putative inner membrane protein,,
6532	putative inner membrane protein				P0A1V1(1)
6533	putative cytoplasmic protein,
6534	putative cytoplasmic protein,
6536	putative ribulose-5-phosphate 3-epimerase\|Ribulose-5-phosphate 3-epimerase (RPE); cd00429
6537	putative Mannose-6-phosphate isomerase\|Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; COG1917	COG1917(4)
6538	putative regulatory protein, gntR family\|Transcriptional regulators [Transcription]; COG2188\|helix_turn_helix gluconate operon transcriptional repressor; smart00345\|UTRA domain. The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345; pfam07702	COG2188(4)	PF07702(4)	SM00345(4)
6539	putative ADP-ribosylglycohydrolase\|ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; COG1397	COG1397(4)
6540	putative inner membrane protein,
6541	putative inner membrane lipoprotein
6542	putative inner membrane protein,
6543	putative outer membrane protein,
6544	hypothetical protein
6545	hypothetical protein
6546	putative outer membrane protein\|Saf-pilin pilus formation protein. This domain consists of the adjacent Saf-Nte and Saf-pilin chains of the pilus-forming complex; pfam09460		PF09460(4)
6547	transcriptional regulator\|Transcriptional regulator [Transcription]; COG0583\|Bacterial regulatory helix-turn-helix protein, lysR family; pfam00126\|LysR substrate binding domain. The structure of this domain is known and is similar to the periplasmic binding proteins; pfam03466	COG0583(4)	PF00126(4)\|PF03466(4)
6548	putative inner membrane protein\|DNA-binding winged-HTH domains [Transcription]; COG3710	COG3710(4)
6549	putative periplasmic protein,,
6550	putative response regulator\|DNA-binding HTH domain-containing proteins [Transcription]; COG2771\|IPR000792: Bacterial regulatory protein, LuxR family	COG2197(3)\|COG2771(3), COG2771(1)
6551	putative inner membrane protein,,
6552	conserved hypothetical protein\|FOG: TPR repeat, SEL1 subfamily [General function prediction only]; COG0790\|Sel1-like repeats. These represent a subfamily of TPR (tetratricopeptide repeat) sequences; smart00671	COG0790(4)		SM00671(4)
6553	putative hydrolase N-terminus\|Altronate dehydratase [Carbohydrate transport and metabolism]; COG2721	COG2721(4)
6554	putative sigma-54 dependent transcriptional regulator\|Propionate catabolism activator. This domain is found at the N terminus of several sigma54- dependent transcriptional activators including PrpR, which activates catabolism of propionate; pfam06506\|Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; COG3829\|AAA-superfamily of ATPases associated with a wide variety of cellular activities, including membrane fusion, proteolysis, and DNA replication; cd00009\|IPR002078: Sigma-54 factor interaction domain; IPR002197: Helix-turn-helix, Fis-type	COG3829(3)	PF06506(3)
6555	putative inner membrane protein\|Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; COG4714	COG4714(4)
6556	putative transcriptional regulator, Lrp family\|Na+/alanine symporter [Amino acid transport and metabolism]; COG1115\|IPR001463: Sodium:alanine symporter; IPR002293: Amino acid/polyamine transporter, family I	COG1115(4)
6557	putative periplasmic protein,
6558	Secretion system apparatus SsaM,
6559	hypothetical protein
6560	putative inner membrane protein,
6561	putative inner membrane protein
6562	hypothetical protein
6564	putative inner membrane protein,,
6565	putative inner membrane protein,
6566	putative inner membrane protein,,
6567	homolog of virulence protein MsgA
6569	putative cytoplasmic protein
6570	putative ketopantoate reductase\|2-dehydropantoate 2-reductase; PRK12921\|Ketopantoate reductase PanE/ApbA. This is a family of 2-dehydropantoate 2-reductases also known as ketopantoate reductases, EC:1.1.1.169. The reaction catalysed by this enzyme is: (R)-pantoate + NADP(+) <=> 2-dehydropantoate + NADPH; pfam02558\|IPR000205: NAD-binding site		PF02558(4)\|PF08546(4)
6571	putative transcriptional regulator, LysR family\|Transcriptional regulator [Transcription]; COG0583\|Bacterial regulatory helix-turn-helix protein, lysR family; pfam00126\|LysR substrate binding domain. The structure of this domain is known and is similar to the periplasmic binding proteins; pfam03466\|IPR000847: Bacterial regulatory protein LysR, HTH motif	COG0583(4)	PF00126(4)\|PF03466(4)
6572	putative nitrite reductase,
6574	hypothetical protein\|similar to Salmonella typhi CT18 hypothetical protein
6585	putative sodium/glucose cotransporter\|Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; COG0591	COG0591(3)
6586	putative hydrogenase protein\|HupF/HypC family; pfam01455\|IPR001109: Hydrogenase expression/formation protein (HUPF/HYPC)		PF01455(3)
6587	translocated effector SifB\|secreted effector protein; PRK09499
6588	putative inner membrane protein,,
6590	putative glucose-6-phosphate dehydrogenase,,
6591	putative inner membrane protein
6592	putative cytoplasmic protein
6593	putative cytoplasmic protein
6594	hypothetical protein\|TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria; cd01298\|Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site; cd01307\|similar to Salmonella typhi CT18 hypothetical protein
6595	putative cytoplasmic protein,
6596	invasin-like protein\|predicted invasin; PRK10177\|Similar to Yersinia pseudotuberculosis invasin SW:INVA_YERPS (P11922) (985 aa) fasta scores: E(): 0, 30.3% id in 534 aa, and to Salmonella typhi invasin-like SivH sivH TR:AAF65573 (EMBL:AF247160) (626 aa) fasta scores: E(): 7.9e-32, 33.0% id in 379 aa, and to Escherichia coli hypothetical 47.0 kDa protein in chac-narl intergenic region ychO SW:YCHO_ECOLI (P39165; P46124; P76022) (417 aa) fasta scores: E(): 6.5e-30, 30.5% id in 377 aa
6597	putative ABC-type polar amino acid transport system, ATPase component\|HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; cd03262\|IPR001687: ATP/GTP-binding site motif A (P-loop); IPR003439: ABC transporter	COG1126(3)
6598	putative amino acid ABC transporter permease component	COG0765(3)
6599	hypothetical protein\|S-adenosylmethionine:tRNA-ribosyltransferase- isomerase (queuine synthetase) [Translation, ribosomal structure and biogenesis]; COG0809\|Protein of unknown function (DUF1493). This family consists of several bacterial proteins of around 115 residues in length; pfam07377	COG0809(3)	PF07377(1)
6600	putative hydrogenase\|Hydrogenase expression/synthesis hypA family. Four conserved cysteines lie either side of the least conserved region; pfam01155\|IPR000688: Hydrogenase expression/synthesis, HypA family		PF01155(2)
6601	hypothetical protein
6603	putative membrane protein,